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Text File  |  1987-10-07  |  530b  |  15 lines
  1.  
  2.          IN PATIENTS WITH RENAL IMPAIRMENT, METHADONE DOSAGE SHOULD BE
  3.          CAREFULLY ADJUSTED TO AVOID TOXICITY (EXCESSIVE SEDATION AND
  4.          RESPIRATORY DEPRESSION).
  5.           
  6.          SOME CLINICIANS RECOMMEND THAT THE DOSAGE REGIMEN BE ADJUSTED
  7.          BASED ON THE PATIENT'S CREATININE CLEARANCE:
  8.           
  9.                      CREATININE
  10.                       CLEARANCE           DOSAGE
  11.                      (ML/MINUTE)
  12.           
  13.                         <10          50 to 75% of normal
  14.           
  15.